GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9815354 | 1 | rs13325965 | chr3:41914942 | ULK4 | chr3:41288091-42003660:- | 0.95 | 9.28 | 5.58E-15 | Diastolic blood pressure |
| THYM | cis | rs8050907 | 1 | rs13335998 | chr16:4651921 | NMRAL1 | chr16:4511696-4526307:- | -0.5 | -5.61 | 1.96E-7 | Obesity-related traits |
| THYM | cis | rs1577917 | 1 | rs1337844 | chr6:86677273 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs1577917 | 1 | rs1337850 | chr6:86729103 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.96 | 4.28E-10 | Response to antipsychotic treatment |
| THYM | cis | rs7223966 | 1 | rs13380863 | chr17:61780793 | TCAM1P | chr17:61934376-61941738:+ | -0.54 | -4.13 | 7.81E-5 | Body mass index |
| THYM | cis | rs9309473 | 1 | rs13383871 | chr2:73631779 | ALMS1P | chr2:73872046-73912692:+ | 0.63 | 4.58 | 1.4E-5 | Metabolite levels |
| THYM | cis | rs13385191 | 1 | rs13385191 | chr2:20888265 | C2orf43 | chr2:20883803-21022827:- | -0.63 | -7.64 | 1.72E-11 | Prostate cancer |
| THYM | cis | rs9309473 | 1 | rs13398956 | chr2:73720258 | ALMS1P | chr2:73872046-73912692:+ | 0.59 | 4.59 | 1.34E-5 | Metabolite levels |
| THYM | cis | rs9309473 | 1 | rs13421462 | chr2:73719875 | ALMS1P | chr2:73872046-73912692:+ | 0.62 | 4.72 | 8.24E-6 | Metabolite levels |
| THYM | cis | rs9309473 | 1 | rs13428235 | chr2:73633430 | ALMS1P | chr2:73872046-73912692:+ | 0.62 | 4.72 | 8.01E-6 | Metabolite levels |
| THYM | cis | rs9309473 | 1 | rs13431267 | chr2:73782200 | ALMS1P | chr2:73872046-73912692:+ | 0.59 | 4.53 | 1.69E-5 | Metabolite levels |
| THYM | cis | rs9309473 | 1 | rs13432605 | chr2:73810981 | ALMS1P | chr2:73872046-73912692:+ | 0.59 | 4.56 | 1.53E-5 | Metabolite levels |
| THYM | cis | rs3820928 | 1 | rs1346618 | chr2:227771988 | RHBDD1 | chr2:227700773-227861591:+ | 0.31 | 4.56 | 1.54E-5 | Pulmonary function |
| THYM | cis | rs5758659 | 1 | rs134869 | chr22:42652074 | CYP2D6 | chr22:42522502-42526883:- | -0.69 | -7.37 | 6.15E-11 | Cognitive function |
| THYM | cis | rs5758659 | 1 | rs134873 | chr22:42657566 | CYP2D6 | chr22:42522502-42526883:- | -0.68 | -7.31 | 8.39E-11 | Cognitive function |